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Titel:

Age-related myelin degradation burdens the clearance function of microglia during aging.

Dokumenttyp:
journal article
Autor(en):
Safaiyan, Shima; Kannaiyan, Nirmal; Snaidero, Nicolas; Brioschi, Simone; Biber, Knut; Yona, Simon; Edinger, Aimee L; Jung, Steffen; Rossner, Moritz J; Simons, Mikael
Abstract:
Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunc...     »
Zeitschriftentitel:
Nat Neurosci
Jahr:
2016
Band / Volume:
19
Heft / Issue:
8
Seitenangaben Beitrag:
995-8
Sprache:
eng
Volltext / DOI:
doi:10.1038/nn.4325
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27294511
Print-ISSN:
1097-6256
TUM Einrichtung:
Institut für Zellbiologie des Nervensystems
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