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Titel:

Impairments of neural circuit function in Alzheimer's disease.

Dokumenttyp:
Journal Article; Review; Review
Autor(en):
Busche, Marc Aurel; Konnerth, Arthur
Abstract:
An essential feature of Alzheimer's disease (AD) is the accumulation of amyloid-? (A?) peptides in the brain, many years to decades before the onset of overt cognitive symptoms. We suggest that during this very extended early phase of the disease, soluble A? oligomers and amyloid plaques alter the function of local neuronal circuits and large-scale networks by disrupting the balance of synaptic excitation and inhibition (E/I balance) in the brain. The analysis of mouse models of AD revealed that...     »
Zeitschriftentitel:
Philos Trans R Soc Lond B Biol Sci
Jahr:
2016
Band / Volume:
371
Heft / Issue:
1700
Sprache:
eng
Volltext / DOI:
doi:10.1098/rstb.2015.0429
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27377723
Print-ISSN:
0962-8436
TUM Einrichtung:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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