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Title:

Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Langfelder, Antonia; Okonji, Emeka; Deca, Diana; Wei, Wei-Chun; Glitsch, Maike D
Abstract:
Microglia are the resident macrophage and immune cell of the brain and are critically involved in combating disease and assaults on the brain. Virtually all brain pathologies are accompanied by acidosis of the interstitial fluid, meaning that microglia are exposed to an acidic environment. However, little is known about how extracellular acidosis impacts on microglial function. The activity of microglia is tightly controlled by 'on' and 'off' signals, the presence or absence of which results in...     »
Journal title abbreviation:
Cell Calcium
Year:
2015
Journal volume:
57
Journal issue:
4
Pages contribution:
247-56
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ceca.2015.01.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25623949
Print-ISSN:
0143-4160
TUM Institution:
Institut für Neurowissenschaften
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