Decreased amyloid-? and increased neuronal hyperactivity by immunotherapy in Alzheimer's models.

Title:: Decreased amyloid-? and increased neuronal hyperactivity by immunotherapy in Alzheimer's models.
Document type:: Journal Article; Research Support, Non-U.S. Gov't
Author(s):: Busche, Marc Aurel; Grienberger, Christine; Keskin, Aylin D; Song, Beomjong; Neumann, Ulf; Staufenbiel, Matthias; Förstl, Hans; Konnerth, Arthur
Abstract:: Among the most promising approaches for treating Alzheimer's disease is immunotherapy with amyloid-? (A?)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to A? used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.
Journal title abbreviation:: Nat Neurosci
Year:: 2015
Journal volume:: 18
Journal issue:: 12
Pages contribution:: 1725-7
Language:: eng
Fulltext / DOI:: doi:10.1038/nn.4163
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/26551546
Print-ISSN:: 1097-6256
TUM Institution:: Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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