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Title:

Rescue of long-range circuit dysfunction in Alzheimer's disease models.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Author(s):
Busche, Marc Aurel; Keku?, Maja; Adelsberger, Helmuth; Noda, Takahiro; Förstl, Hans; Nelken, Israel; Konnerth, Arthur
Abstract:
Alzheimer's disease (AD) is associated with defects of synaptic connectivity. Such defects may not be restricted to local neuronal interactions but may extend to long-range brain activities, such as slow-wave oscillations that are particularly prominent during non-rapid eye movement (non-REM) sleep and are important for integration of information across distant brain regions involved in memory consolidation. There is increasing evidence that sleep is often impaired in AD, but it is unclear wheth...     »
Journal title abbreviation:
Nat Neurosci
Year:
2015
Journal volume:
18
Journal issue:
11
Pages contribution:
1623-30
Language:
eng
Fulltext / DOI:
doi:10.1038/nn.4137
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26457554
Print-ISSN:
1097-6256
TUM Institution:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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