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- Title:
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
- Document type:
- Article
- Author(s):
- Lehmann, J; Vomacka, J; Esser, K; Nodwell, M; Kolbe, K; Ramer, P; Protzer, U; Reiling, N; Sieber, SA
- Abstract:
- Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.
- Journal title abbreviation:
- MedChemComm
- Year:
- 2016
- Journal volume:
- 7
- Journal issue:
- 9
- Pages contribution:
- 1797-1801
- Language:
- eng
- Print-ISSN:
- 2040-2503
- TUM Institution:
- Institut für Virologie
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