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Titel:

Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas.

Dokumenttyp:
journal article
Autor(en):
Lee, Misu, M; Wiedemann, Tobias, T; Gross, Claudia, C; Leinhäuser, Ines, I; Roncaroli, Federico, F; Braren, Rickmer, R; Pellegata, Natalia S, NS
Abstract:
Novel therapeutic approaches are needed to improve the postoperative management of residual nonfunctioning pituitary adenomas (NFPA), given their high relapse rate. Here, we evaluated the antitumor efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in the only available model of spontaneous NFPAs (MENX rats).Organotypic cultures of rat primary NFPAs were incubated with NVP-BEZ235 and assessed for cell viability, proliferation, apoptosis, and PI3K/mTOR inhibition. NVP-BEZ235, or placebo, was adm...     »
Zeitschriftentitel:
Clin Cancer Res
Jahr:
2015
Band / Volume:
21
Heft / Issue:
14
Seitenangaben Beitrag:
3204-15
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25838390
Print-ISSN:
1078-0432
TUM Einrichtung:
Institut für Radiologie
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