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Titel:

IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Guenova, Emmanuella; Skabytska, Yuliya; Hoetzenecker, Wolfram; Weindl, Günther; Sauer, Karin; Tham, Manuela; Kim, Kyu-Won; Park, Ji-Hyeon; Seo, Ji Hae; Ignatova, Desislava; Cozzio, Antonio; Levesque, Mitchell P; Volz, Thomas; Köberle, Martin; Kaesler, Susanne; Thomas, Peter; Mailhammer, Reinhard; Ghoreschi, Kamran; Schäkel, Knut; Amarov, Boyko; Eichner, Martin; Schaller, Martin; Clark, Rachael A; Röcken, Martin; Biedermann, Tilo
Abstract:
Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-?-producing T(H)1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on th...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2015
Band / Volume:
112
Heft / Issue:
7
Seitenangaben Beitrag:
2163-8
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1416922112
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25646481
Print-ISSN:
0027-8424
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie
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