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Title:

Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Groneberg, Dieter; Zizer, Eugen; Lies, Barbara; Seidler, Barbara; Saur, Dieter; Wagner, Martin; Friebe, Andreas
Abstract:
Oesophageal achalasia is a disease known to result from reduced relaxation of the lower oesophageal sphincter (LES). Nitric oxide (NO) is one of the main inhibitory transmitters. NO-sensitive guanylyl cyclase (NO-GC) acts as the key target of NO and, by the generation of cGMP, mediates nitrergic relaxation in the LES. To date, the exact mechanism of nitrergic LES relaxation is still insufficiently elucidated. To clarify the role of NO-GC in LES relaxation, we used cell-specific knockout (KO) mou...     »
Journal title abbreviation:
J Physiol
Year:
2015
Journal volume:
593
Journal issue:
2
Pages contribution:
403-14
Language:
eng
Fulltext / DOI:
doi:10.1113/jphysiol.2014.273540
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25630261
Print-ISSN:
0022-3751
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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