The goal of the research described in this thesis was to improve current imaging methods for nuclear magnetic resonance acquisitions with hyperpolarised biomarkers, and to apply these improved techniques to preclinical in vivo studies in order to validate their performance. Beginning with advanced pulse sequence design and reconstruction methods, a broad spectrum of biomedical applications is discussed and new methods to increase the diagnostic value of hyperpolarised examinations are presented.      «

The goal of the research described in this thesis was to improve current imaging methods for nuclear magnetic resonance acquisitions with hyperpolarised biomarkers, and to apply these improved techniques to preclinical in vivo studies in order to validate their performance. Beginning with advanced pulse sequence design and reconstruction methods, a broad spectrum of biomedical applications is discussed and new methods to increase the diagnostic value of hyperpolarised examinations are presented....     »