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Titel:

Craniospinal irradiation with concurrent temozolomide for primary metastatic pediatric high-grade or diffuse intrinsic pontine gliomas. A first report from the GPOH-HIT-HGG Study Group.

Dokumenttyp:
Case Reports; Journal Article; Article
Autor(en):
Müller, K; Schlamann, A; Guckenberger, M; Warmuth-Metz, M; Glück, A; Pietschmann, S; Wawer, A; Kortmann, R-D; Kramm, C; von Bueren, A O
Abstract:
High-grade (HGG) and diffuse intrinsic pontine gliomas (DIPG) with primary metastatic spread are extremely rare and have a dismal prognosis. Analogous to simultaneous radiochemotherapy in non-metastatic HGG and DIPG, concurrent craniospinal irradiation (CSI) and metronomic temozolomide (metroTMZ) may represent a reasonable therapeutic approach. However, the antitumor efficacy and toxicity of this treatment still have to be investigated.Between March 2007 and December 2012, six children with prim...     »
Zeitschriftentitel:
Strahlenther Onkol
Jahr:
2014
Band / Volume:
190
Heft / Issue:
4
Seitenangaben Beitrag:
377-81
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00066-013-0513-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24638239
Print-ISSN:
0179-7158
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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