Risk of Guillain-Barré syndrome following pandemic influenza A(H1N1) 2009 vaccination in Germany.

Prestel, Jürgen; Volkers, Peter; Mentzer, Dirk; Lehmann, Helmar C; Hartung, Hans-Peter; Keller-Stanislawski, Brigitte; GBS Study Group; Gerber, Joachim; Heyden, Max; Klötzsch, Christof; Linster, Eveline; Langel, Stefan; Bößenecker, Wolfgang; Bamberg, Christian; Gerlach, Roland; Reckhardt, Markus; Borak, Peter; Braun, Holger; Harzheim, Michael; Isenhardt, Klaus; Bader, Peter; Glocker, Franz; Reimers, Carl D; Riesterer-Hemm, Gertraud; Trabold, René; Homberg, Vivien; Klee, Rolf; von Rosen, Friedrich; Daffertshofer, Michael; Hofler, Dieter; Hofstadt, Ulrich; Baumsteiger, Christoph; Dreger, Jens; Stachulski, Frank; Harms, Hendrik; Kauert, Andreas; Haas, Judith; von Brevern, Michael; Völzke, Enrico; Ducke, Franziska; Böhme, Horst; Koennecke, Hans-Christian; Ecke, Alexander; Koennecke, Hans-Christian; Bähr, Dieter; Nabavi, Darius Günther; Hopmann, Dominik; Porz, Dennis; Neumayer, Bettina; Müller, Thomas; Kitzrow, Martin; Börnke, Christian; Schröder, Alexa; Kowalski, Thomas; Günther, Johannes; Boeckler, David; Reinshagen, Alexander; Sarholz, Michael; Böhm, Klaus-Dieter; Weiland, Tobias; Kuhlmann, Ralf-Jochen; Heide, Wolfgang; Heider, Steffen; Schüler, Olaf; Schepelmann, Karsten; Claus, Detlef; Kunesch, Erwin; Yaretskyy, Grygoriy; Spieker, Sybille; Jung, Stefan; Spitzer, Christoph; Busch, Alexander; Schneider, Hauke; Machetanz, Jochen; Grehl, Holger; Nolden-Koch, Martina; Wilmsen, Herbert; Lehmann, Helmar; Seitz, Rüdiger; Griese, Mechthild; Schmitt, Hans-Michael; Dietze, Christoph; Holz, Jan; Leinisch, Elke; Derfuß, Tobias; Linker, Ralf; Reinhardt, Frank-M; Krämer, Markus; Koeppen, Susanne; Gerhard, Horst; Bauer, Hartmut; Stolze, Henning; Jost, Volker; Steinmetz, Helmuth; Schütz, Hansjörg; Böhm, Josef; Rauer, Sebastian; Klotz, Jürgen M; Schneider, Andreas; Biemann, Michael; Blaes, Franz; Krämer, Heidrun; Guthke, Kersten; Schmidt, Holger; Krumpolt, Holm; Schiess, Dörthe; Roth, Matthias; Fuchs, Hans-Hermann; Schneider, Edda; Wohlfarth, Kai; Müller, Tobias; Sick, Walter; Schwandt, Dietrich; Wellach, Ingmar; Töpper, Rudolf Friedrich; Koehler, Jürgen; Rosenkranz, Thorsten; Knepel, Sven; Duwe, Thomas; Stiller, Mark; Rieke, Klaus; Baas, Horst; Brunotte, Peter; Tümmler, Johanna; Heidenreich, Fedor; Stangel, Martin; Stift, Tatjana; Ringleb, Peter; Kaendler, Stephen; Humbroich, Knut; Plöger, Helmut; Sitzer, Matthias; Dieter, Jens; Dietz, Maik; Eicke, Martin; Ochs, Günter; Güldenring, Antje; Hagemann, Georg; Zinke, Jan; Fetter, Michael; Herath, Harald; Escheu, Gabriele; Stingele, Robert; Berthold, Ameli; Schmitt, Eberhard; Haupt, Walter F; Petereit, Hela-F; Limmroth, Volker; von Giesen, Hans-Jürgen; Kirsch, Benno; Heckmann, Josef G; Beuche, Wolfgang; Schattenfroh, Christoph; Tampier-Pohl, Christina; Friedl, Raphael; Oberwittler, Christoph; Schlenker, Michael; Trillenberg, Peter; Abushammala, Ali; Schabet, Martin; Eßer, Marcus; Thümen, Ansgar; Lins, Hartmut; Vielhaber, Stefan; Bayerl, Johannes; Tackenberg, Björn; Hachgenei, Andreas; Meisenheim, Glantal-Klinik; Philipps, Jörg; Tings, Tobias; Franz, Oliver; Jauß, Marek; Berthele, Achim; München, T U; Hupfer, Wolfgang; Nagi, Michael; Dziewas, Rainer; Kusch, Wolfgang; Lobenstein, Sabine; Fischer, Volkmar; Syed, Nadeem; Bitsch, Andreas; Jahnke, Uwe; Allendörfer, Jens; Dietrich, Wenke; Görtzen, Angelika; Stark, Erwin; Wenning, Werner; Neumann, Frank; Petrick, Marko; Kaiser, Reinhard; Niehoff, Torsten; Deymann, Ralph; Hartmann, Ronald; Christe, Walter; Görlitz, Carsten; Hotz, Michael; Buchner, Helmut; Balzer, Kathrin; Braune, Hans Joachim; Kindl, Hans-Joachim; Leschnik, Olaf; Lohner, Hanns; Zettl, Uwe; Kiefer, Reinhard; Krauth, Sebastian; Hansberg, Tjark; Matrisch, Helge; Vetter, Thomas; Schepelmann, Karsten; Schade, Bernd; Nguento, Alain; Fortwängler, Thorsten; Hartnack, Fritz; Neuhaus, Oliver; Wennrich, Michael; Leopold, Hans Claus; Tebben, Jörg; Polzer, Udo; Sieb, Peter; Huss, Georg-Peter; Kuhl, Valerio; Gawlitza, Michael; Freudenberger, Thomas; Rieder, Georg; Schröder, Kerstin; Bös, Monika; Krüger, Thomas; Rechlin, Matthias; Bufler, Johannes; Angerer, Michael; Möller, Peter; Eppinger, Burckhardt; Dömges, Frank; Albrecht, Peter; Kotterba, Sylvia; Stolz, Erwin; Schmidt, Nikolaus; Trottenberg, Thomas; Feige, Philipp; Hufschmidt, Andreas; Svrakova, Lidia; Haensch, Carl-Albrecht; Kastrau, Frank; Schmidt, Patrick; Reiners, Karlheinz; Weinmann, Erik; Merkelbach, Stefan; Bachhuber, Armin; Hermann, Wieland; Häusler, Martin; Toth, Monika; Weiß, Bernt Martin; Stein, Detlef; Klepper, Jörg; Hirsch, Thomas; von Moers, Arpad; Brandes, Heiko; Botsch, Micha; Köhler, Cornelia; Franke, Ingo; Kössel, Hans; Kauffmann, Birgit; Schwalm, Hanno; Kirschstein, Martin; Tribukait, Ulrich; Mandl, Michael; Böhmann, Hans; Schaetz, Kirstin; Hebing, Burkhard; Steinert, Martin; Eichholz, Stephan; von Lilien-Waldau, Tassilo; Karenfort, Michael; Kretzschmar, Benno; Trollmann, Regina; Schmiedel, Gudrun; Dördelmann, Michael; Kieslich, Matthias; Mause, Ulrike; Grüber, Christoph; Korinthenberg, Rudolf; Heubner, Georg; Mattes, Jasmin; Radlow, Udo; Repp, Reinald; Klinge, Jens; Genseke, Rainer; Gsinn, Stefan; Gebhardt, Boris; Papsch, Matthias; Mutlak, Suhail; Brockmann, Knut; Koch, Gerhard; Mandelkow, Frank; v Blanckenburg, Philipp; Bertram, Uwe; Vieker, Silvia; Peltner, Hans-Ulrich; Sander, Marina; Shamdeen, Mohammed Ghiath; Nowka, Sigrid; Koch, Walter; Walkenhorst, Hartmut; Rubens, Thomas; Westerbeck, Klaus; Rübo, Jochen; Wiater, Alfred; Pflumm, Karin; Bensch, Jürgen; Engelhardt, Harald; Deja, Margot; Borte, Michael; Tibussek, Daniel; Bosse, Henry; Rinschen, Karla; Härtel, Christoph; Gaude-Wagener, Michael; Beyer, Uta; Pädiatrie, Allgemeine; Peters, Helmut; Kowalzik, Frank; Seipelt, Peter; Zippel, Stephanie; Pargac, Kai Nils; Schobeß, Axel; Müller, Wolfgang; Baethmann, Martina; Leiz, Steffen; Gehrmann, Armin; Makowski, Christine; Fiedler, Barbara; Böswald, Michael; Weisbrod, Tanja; Kintzel, Kathrin; Franz, Christel; Feickert, Hans-Joachim; Kühl, Peter Gonne; Schneider, Michael; Raab, Klaus; Beyer, Peter; Kauther, Klaus-Dieter; Reiter, Hans-Ludwig; Heubner, Georg; Behl, Eva-Susanne; Trefz, Friedrich K; Hoffmann, Hans-Georg; Buss, Michael; Olbertz, Dirk M; Hempel, Lutz; Agricola, Georgius; Horneff, Gerd; Augustin, Kinderklinik Sankt; Mihatsch, Walter; Kurre, Anja; Colling, Steffi; Burghard, Rainer; Soditt, Volker; Feierfeil, Kristin; Hornbrook, Daniela; Kellner, Lars; Pernice, Walter; Schirmer, Doris; Alber, Michael; Geerken, Swen; Kratz, Michael; Köhler, André; Knuf, Markus; Repinska, Tetyana; Buller, Maria; Becker, Jan-Claudius; Niesytto, Christian; Skopnik, Heino; Borusiak, Peter; Verbeek, Tilman; Gabler, Ingrid; Winkelmann, Thomas     «

Prestel, Jürgen; Volkers, Peter; Mentzer, Dirk; Lehmann, Helmar C; Hartung, Hans-Peter; Keller-Stanislawski, Brigitte; GBS Study Group; Gerber, Joachim; Heyden, Max; Klötzsch, Christof; Linster, Eveline; Langel, Stefan; Bößenecker, Wolfgang; Bamberg, Christian; Gerlach, Roland; Reckhardt, Markus; Borak, Peter; Braun, Holger; Harzheim, Michael; Isenhardt, Klaus; Bader, Peter; Glocker, Franz; Reimers, Carl D; Riesterer-Hemm, Gertraud; Trabold, René; Homberg, Vivien; Klee, Rolf; von Rosen, Friedric...     »

A prospective, epidemiologic study was conducted to assess whether the 2009 pandemic influenza A(H1N1) vaccination in Germany almost exclusively using an AS03-adjuvanted vaccine (Pandemrix) impacts the risk of Guillain-Barré syndrome (GBS) and its variant Fisher syndrome (FS).Potential cases of GBS/FS were reported by 351 participating hospitals throughout Germany. The self-controlled case series methodology was applied to all GBS/FS cases fulfilling the Brighton Collaboration (BC) case definition (levels 1-3 of diagnostic certainty) with symptom onset between 1 November 2009 and 30 September 2010 reported until end of December 2010.Out of 676 GBS/FS reports, in 30 cases, GBS/FS (BC levels 1-3) occurred within 150 days following influenza A(H1N1) vaccination. The relative incidence of GBS/FS within the primary risk period (days 5-42 post-vaccination) compared with the control period (days 43-150 post-vaccination) was 4.65 (95%CI [2.17, 9.98]). Similar results were found when stratifying for infections within 3 weeks prior to onset of GBS/FS and when excluding cases with additional seasonal influenza vaccination. The overall result of temporally adjusted analyses supported the primary finding of an increased relative incidence of GBS/FS following influenza A(H1N1) vaccination.The results indicate an increased risk of GBS/FS in temporal association with pandemic influenza A(H1N1) vaccination in Germany.     «

A prospective, epidemiologic study was conducted to assess whether the 2009 pandemic influenza A(H1N1) vaccination in Germany almost exclusively using an AS03-adjuvanted vaccine (Pandemrix) impacts the risk of Guillain-Barré syndrome (GBS) and its variant Fisher syndrome (FS).Potential cases of GBS/FS were reported by 351 participating hospitals throughout Germany. The self-controlled case series methodology was applied to all GBS/FS cases fulfilling the Brighton Collaboration (BC) case definiti...     »