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Title:

Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Cun, Yanping; Tang, Lin; Yan, Jie; He, Chao; Li, Yang; Hu, Zhian; Xia, Jianxia
Abstract:
Orexin neurons within the lateral hypothalamus play a crucial role in the promotion and maintenance of arousal. Studies have strongly suggested that orexin neurons are an important target in endogenous adenosine-regulated sleep homeostasis. Orexin A induces a robust increase in the firing activity of orexin neurons, while adenosine has an inhibitory effect. Whether the excitatory action of orexins in the lateral hypothalamus actually promotes wakefulness and reverses the sleep-producing effect o...     »
Journal title abbreviation:
Neurosci Bull
Year:
2014
Journal volume:
30
Journal issue:
5
Pages contribution:
877-86
Language:
eng
Fulltext / DOI:
doi:10.1007/s12264-013-1442-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24898402
Print-ISSN:
1673-7067
TUM Institution:
Institut für Neurowissenschaften
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