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Titel:

Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review
Autor(en):
Ahles, Andrea; Engelhardt, Stefan
Abstract:
The human genome encodes nine different adrenoceptor genes. These are grouped into three families, namely, the ?1-, ?2-, and ?-adrenoceptors, with three family members each. Adrenoceptors are expressed by most cell types of the human body and are primary targets of the catecholamines epinephrine and norepinephrine that are released from the sympathetic nervous system during its activation. Upon catecholamine binding, adrenoceptors change conformation, couple to and activate G proteins, and there...     »
Zeitschriftentitel:
Pharmacol Rev
Jahr:
2014
Band / Volume:
66
Heft / Issue:
3
Seitenangaben Beitrag:
598-637
Sprache:
eng
Volltext / DOI:
doi:10.1124/pr.113.008219
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24928328
Print-ISSN:
0031-6997
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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