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Title:

Tetra-acetylajugasterone a new constituent of Vitex cienkowskii with vasorelaxant activity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Dongmo, Alain Bertrand; Nkeng-Efouet, Pepin Alango; Devkota, Krishna Prasad; Wegener, Jörg W; Sewald, Norbert; Wagner, Hildebert; Vierling, Wolfgang
Abstract:
Tetra-acetylajugasterone C (TAAC) was found to be one of the naturally occurring compounds of the Cameroonian medicinal plant Vitex cienkowskii which is responsible for a vasorelaxant activity of an extract of this plant. The evaluation of the underlying mechanisms for the relaxing effect of TAAC was determined using aortic rings of rats and mice. TAAC produced a concentration-dependent relaxation in rat artery rings pre-contracted with 1?M noradrenaline (IC50: 8.40?M) or 60mM KCl (IC50: 36.30?M...     »
Journal title abbreviation:
Phytomedicine
Year:
2014
Journal volume:
21
Journal issue:
6
Pages contribution:
787-92
Language:
eng
Fulltext / DOI:
doi:10.1016/j.phymed.2014.02.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24680617
Print-ISSN:
0944-7113
TUM Institution:
Institut für Pharmakologie und Toxikologie
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