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Title:

Myelination generates aberrant ultrastructure that is resolved by microglia.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Djannatian, Minou; Radha, Swathi; Weikert, Ulrich; Safaiyan, Shima; Wrede, Christoph; Deichsel, Cassandra; Kislinger, Georg; Rhomberg, Agata; Ruhwedel, Torben; Campbell, Douglas S; van Ham, Tjakko; Schmid, Bettina; Hegermann, Jan; Möbius, Wiebke; Schifferer, Martina; Simons, Mikael
Abstract:
To enable rapid propagation of action potentials, axons are ensheathed by myelin, a multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is generated early in development, resulting in the generation of long-lasting stable membrane structures. Here, we explored structural and dynamic changes in central nervous system myelin during development. To achieve this, we performed an ultrastructural analysis of mouse optic nerves by serial block face scanning electron microsco...     »
Journal title abbreviation:
J Cell Biol
Year:
2023
Journal volume:
222
Journal issue:
3
Fulltext / DOI:
doi:10.1083/jcb.202204010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36637807
Print-ISSN:
0021-9525
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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