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Title:

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.

Document type:
Journal Article
Author(s):
Depp, Constanze; Sun, Ting; Sasmita, Andrew Octavian; Spieth, Lena; Berghoff, Stefan A; Nazarenko, Taisiia; Overhoff, Katharina; Steixner-Kumar, Agnes A; Subramanian, Swati; Arinrad, Sahab; Ruhwedel, Torben; Möbius, Wiebke; Göbbels, Sandra; Saher, Gesine; Werner, Hauke B; Damkou, Alkmini; Zampar, Silvia; Wirths, Oliver; Thalmann, Maik; Simons, Mikael; Saito, Takashi; Saido, Takaomi; Krueger-Burg, Dilja; Kawaguchi, Riki; Willem, Michael; Haass, Christian; Geschwind, Daniel; Ehrenreich, Hannelore;...     »
Abstract:
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocytes and the structural integrity of myelin sheaths1, the latter of which is associated with secondary neuroinflammation2,3. As oligodendrocytes support axonal energy metabolism and neuronal health4-7, we hypothesized that loss of myelin integrity could be an upstream risk factor for neurona...     »
Journal title abbreviation:
Nature
Year:
2023
Journal volume:
618
Journal issue:
7964
Pages contribution:
349-357
Fulltext / DOI:
doi:10.1038/s41586-023-06120-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37258678
Print-ISSN:
0028-0836
TUM Institution:
657; Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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