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Document type:
journal article 
Author(s):
Mazaheri, Fargol; Snaidero, Nicolas; Kleinberger, Gernot; Madore, Charlotte; Daria, Anna; Werner, Georg; Krasemann, Susanne; Capell, Anja; Trümbach, Dietrich; Wurst, Wolfgang; Brunner, Bettina; Bultmann, Sebastian; Tahirovic, Sabina; Kerschensteiner, Martin; Misgeld, Thomas; Butovsky, Oleg; Haass, Christian 
Title:
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. 
Abstract:
Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration. In the brain, TREM2 is predominantly expressed in microglia. Several disease-associated TREM2 variants result in a loss of function by reducing microglial phagocytosis, impairing lipid sensing, preventing binding of lipoproteins and affecting shielding of amyloid plaques. We her...    »
 
Journal title abbreviation:
EMBO Rep 
Year:
2017 
Journal volume:
18 
Journal issue:
Pages contribution:
1186-1198 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1469-221X 
TUM Institution:
Institut für Zellbiologie des Nervensystems