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Title:

Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tai, Yi-Heng; Engels, Daniel; Locatelli, Giuseppe; Emmanouilidis, Ioanna; Fecher, Caroline; Theodorou, Delphine; Müller, Stephan A; Licht-Mayer, Simon; Kreutzfeldt, Mario; Wagner, Ingrid; de Mello, Natalia Prudente; Gkotzamani, Sofia-Natsouko; Trovò, Laura; Kendirli, Arek; Aljović, Almir; Breckwoldt, Michael O; Naumann, Ronald; Bareyre, Florence M; Perocchi, Fabiana; Mahad, Don; Merkler, Doron; Lichtenthaler, Stefan F; Kerschensteiner, Martin; Misgeld, Thomas
Abstract:
Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell-type-specific mitochondrial proteomics with in vivo biosensor imaging to dissect how inflammation alters the molecular composition and functional capacity of neuronal mitochondria. We show that neuroinflammatory lesions in the mouse spinal cord cause widespread and persisting axonal A...     »
Journal title abbreviation:
Nat Metab
Year:
2023
Journal volume:
5
Journal issue:
8
Pages contribution:
1364-1381
Fulltext / DOI:
doi:10.1038/s42255-023-00838-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37430025
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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