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Title:

Uncoupling of neurogenesis and differentiation during retinal development.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Engerer, Peter; Suzuki, Sachihiro C; Yoshimatsu, Takeshi; Chapouton, Prisca; Obeng, Nancy; Odermatt, Benjamin; Williams, Philip R; Misgeld, Thomas; Godinho, Leanne
Abstract:
Conventionally, neuronal development is regarded to follow a stereotypic sequence of neurogenesis, migration, and differentiation. We demonstrate that this notion is not a general principle of neuronal development by documenting the timing of mitosis in relation to multiple differentiation events for bipolar cells (BCs) in the zebrafish retina using imaging. We found that BC progenitors undergo terminal neurogenic divisions while in markedly disparate stages of neuronal differentiation. Remarka...     »
Journal title abbreviation:
EMBO J
Year:
2017
Journal volume:
36
Journal issue:
9
Pages contribution:
1134-1146
Language:
eng
Fulltext / DOI:
doi:10.15252/embj.201694230
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28258061
Print-ISSN:
0261-4189
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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