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Titel:

High Concordance of Different Assays in the Determination of Homologous Recombination Deficiency-Associated Genomic Instability in Ovarian Cancer.

Dokumenttyp:
Journal Article
Autor(en):
Pfarr, Nicole; von Schwarzenberg, Karin; Zocholl, Dario; Merkelbach-Bruse, Sabine; Siemanowski, Janna; Mayr, Eva-Maria; Herold, Sylvia; Kleo, Karsten; Heukamp, Lukas C; Willing, Eva-Maria; Menzel, Michael; Lehmann, Ulrich; Bartels, Stephan; Chakraborty, Shounak; Baretton, Gustavo; Demes, Melanie C; Döring, Claudia; Kazdal, Daniel; Budczies, Jan; Rad, Roland; Wild, Peter; Christinat, Yann; McKee, Thomas; Schirmacher, Peter; Horst, David; Büttner, Reinhard; Stenzinger, Albrecht; Sehouli, Jalid; Vo...     »
Abstract:
PURPOSE: Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown promising clinical results in the treatment of ovarian cancer. Analysis of biomarker subgroups consistently revealed higher benefits for patients with homologous recombination deficiency (HRD). The test that is most often used for the detection of HRD in clinical studies is the Myriad myChoice assay. However, other assays can also be used to assess biomarkers, which are indicative of HRD, genomic instability (GI), and BRCA1/2 mut...     »
Zeitschriftentitel:
JCO Precision Oncology
Jahr:
2024
Band / Volume:
8
Volltext / DOI:
doi:10.1200/PO.23.00348
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/38513168
TUM Einrichtung:
Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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