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Title:

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.

Document type:
Journal Article
Author(s):
Afzali, Ali Maisam; Nirschl, Lucy; Sie, Christopher; Pfaller, Monika; Ulianov, Oleksii; Hassler, Tobias; Federle, Christine; Petrozziello, Elisabetta; Kalluri, Sudhakar Reddy; Chen, Hsin Hsiang; Tyystjärvi, Sofia; Muschaweckh, Andreas; Lammens, Katja; Delbridge, Claire; Büttner, Andreas; Steiger, Katja; Seyhan, Gönül; Ottersen, Ole Petter; Öllinger, Rupert; Rad, Roland; Jarosch, Sebastian; Straub, Adrian; Mühlbauer, Anton; Grassmann, Simon; Hemmer, Bernhard; Böttcher, Jan P; Wagner, Ingrid; Kreu...     »
Abstract:
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen1. The immunopathology in neuromyelitis optica is largely driven by autoantibodies to AQP42. However, the T cell response that is required for the generation of these anti-AQP4 antibodies is not well understood. Here we show that B cells endogenously express AQP4 in response to activation with anti-CD40 and IL-21 and are able to present their endog...     »
Journal title abbreviation:
Nature
Year:
2024
Journal volume:
627
Journal issue:
8003
Pages contribution:
407-415
Fulltext / DOI:
doi:10.1038/s41586-024-07079-8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38383779
Print-ISSN:
0028-0836
TUM Institution:
Klinik und Poliklinik für Neurologie (Prof. Hemmer); Molekulare Immunologie (Prof. Knolle); Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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