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Title:

Prototype Digital Lateral Flow Sensor Using Impact Electrochemistry in a Competitive Binding Assay

Document type:
Zeitschriftenaufsatz
Author(s):
Weiß, Lennart J. K.; Rinklin, Philipp; Thakur, Bhawana; Music, Emir; Url, Heike; Kopic, Inola; Hoven, Darius; Banzet, Marko; von Trotha, Tassilo; Mayer, Dirk; Wolfrum, Bernhard
Abstract:
This work demonstrates a lateral flow assay concept on the basis of stochastic-impact electrochemistry. To this end, we first elucidate requirements to employ silver nanoparticles as redox-active labels. Then, we present a prototype that utilizes nanoimpacts from biotinylated silver nanoparticles as readouts to detect free biotin in solution based on competitive binding. The detection is performed in a membrane-based microfluidic system, where free biotin and biotinylated particles compete for s...     »
Journal title:
ACS Sensors
Year:
2022
Journal volume:
7
Journal issue:
7
Pages contribution:
1967-1976
Fulltext / DOI:
doi:10.1021/acssensors.2c00728
Publisher:
American Chemical Society (ACS)
E-ISSN:
2379-36942379-3694
Date of publication:
08.07.2022
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