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Titel:

C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Waldschmitt, N; Berger, E; Rath, E; Sartor, R B; Weigmann, B; Heikenwalder, M; Gerhard, M; Janssen, K-P; Haller, D
Abstract:
Loss of intestinal epithelial cell (IEC) homeostasis and apoptosis negatively affect intestinal barrier function. Uncontrolled activation of the unfolded protein response (UPR) in IEC contributes to an impaired barrier and is implicated in the pathogenesis of inflammatory bowel diseases. However, the contribution of the UPR target gene C/EBP homologous protein (CHOP), an apoptosis-associated transcription factor, to inflammation-related disease susceptibility remains unclear. Consistent with obs...     »
Zeitschriftentitel:
Mucosal Immunol
Jahr:
2014
Band / Volume:
7
Heft / Issue:
6
Seitenangaben Beitrag:
1452-66
Sprache:
eng
Volltext / DOI:
doi:10.1038/mi.2014.34
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24850428
Print-ISSN:
1933-0219
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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