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Titel:

Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.

Dokumenttyp:
journal article
Autor(en):
Sprinzl, Martin Franz, MF; Puschnik, Andreas, A; Schlitter, Anna Melissa, AM; Schad, Arno, A; Ackermann, Kerstin, K; Esposito, Irene, I; Lang, Hauke, H; Galle, Peter Robert, PR; Weinmann, Arndt, A; Heikenwälder, Mathias, M; Protzer, Ulrike, U
Abstract:
Hepatocellular carcinoma (HCC) associated macrophages accelerate tumor progression by growth factor release. Therefore, tumor-associated macrophages (TAM) and their initiated signaling cascades are potential therapeutic targets. Aiming at understanding anticancer effects of systemic HCC therapy we investigated the impact of sorafenib on macrophage function, focusing on macrophage-related growth factor secretion.Macrophage markers, cytokine and growth factor release were investigated in CSF-1 (M1...     »
Zeitschriftentitel:
J Hepatol
Jahr:
2014
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25463538
Print-ISSN:
0168-8278
TUM Einrichtung:
Institut für Virologie
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