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Titel:

PPAR alpha: a novel radiation target in locally exposed Mus musculus heart revealed by quantitative proteomics.

Dokumenttyp:
Journal Article
Autor(en):
Azimzadeh, O; Sievert, W; Sarioglu, H; Yentrapalli, R; Barjaktarovic, Z; Sriharshan, A; Ueffing, M; Janik, D; Aichler, M; Atkinson, MJ; Multhoff, G; Tapio, S
Abstract:
Radiation exposure of the thorax is associated with a markedly increased risk of cardiac morbidity and mortality with a latency period of decades. Although many studies have confirmed the damaging effect of ionizing radiation on the myocardium and cardiac endothelial structure and function, the molecular mechanism behind this damage is not yet elucidated. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a transcriptional regulator of lipid metabolism in heart tissue, has recently r...     »
Zeitschriftentitel:
J Proteome Res
Jahr:
2013
Band / Volume:
12
Heft / Issue:
6
Seitenangaben Beitrag:
2700-14
Sprache:
eng
Volltext / DOI:
doi:10.1021/pr400071g
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23560462
Print-ISSN:
1535-3893
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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