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Titel:

Dynamics of G?i1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Milde, Markus; Rinne, Andreas; Wunder, Frank; Engelhardt, Stefan; Bünemann, Moritz
Abstract:
Many physiological and pathophysiological processes are regulated by cAMP. Different therapies directly or indirectly influence the cellular concentration of this second messenger. A wide variety of receptors either activates or inhibits adenylate cyclases in order to induce proper physiological responses. A key event in this signalling system is the direct and dynamic interaction of G?i1 subunits with adenylate cyclases. We established a FRET-based assay between G-protein subunits and AC5 (type...     »
Zeitschriftentitel:
Biochem J
Jahr:
2013
Band / Volume:
454
Heft / Issue:
3
Seitenangaben Beitrag:
515-23
Sprache:
eng
Volltext / DOI:
doi:10.1042/BJ20130554
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23841650
Print-ISSN:
0264-6021
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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