Suicidal ideation in a European Huntington's disease population.

Hubers, Anna A M; van Duijn, Erik; Roos, Raymund A C; Craufurd, David; Rickards, Hugh; Bernhard Landwehrmeyer, G; van der Mast, Rose C; Giltay, Erik J; REGISTRY investigators of the European Huntington's Disease Network; Bachoud-Lévi, A-C; Bentivoglio, A R; Biunno, I; Bonelli, R M; Burgunder, J-M; Dunnett, S B; Ferreira, J J; Handley, O J; Heiberg, A; llmann, T I; Landwehrmeyer, G B; Levey, J; Ramos-Arroyo, Maria A; Nielsen, J E; ProKoivisto, S; Päivärinta, M; Roos, R A C; Rojo Sebastián, A; Tabrizi, S J; Vandenberghe, W; Verellen- Dumoulin, C; Zaremba, J; Uhrova, T; Wahlström, J; Barth, Katrin; Correia-Guedes, Leonor; Finisterra, Ana Maria; Garde, Monica Bascuñana; Bos, Reineke; Betz, Sabrina; Callaghan, Jenny; Fullam, Ruth; Ecker, Daniel; Nielsen, Mette Gilling; Handley, Olivia J; Hvalstedt, Carina; Held, Christine; Koppers, Kerstin; Laurà, Matilde; Horta, Saul Martinez; Descals, Asunción Martínez; Mestre, Tiago; Minster, Sara; Monza, Daniela; Mütze, Lisanne; Oehmen, Martin; Townhill, Jenny; Orth, Michael; Padieu, Helene; Paterski, Laurent; Peppa, Nadia; Pro Koivisto, Susana; Roedig, Verena; Rialland, Amandine; Røren, Niini; ?a?inková, Pavla; Seliverstov, Yury; Cubillo, Patricia Trigo; Walsem, Marleen Rvan; Wright, Abigail; da Silva, Wildson Vieira; Witjes-Ané, Marie-Noelle; Yudina, Elizaveta; Zielonka, Daniel; Zielonka, Eugeniusz; Zinzi, Paola; Bonelli, Raphael M; Herranhof, Brigitte; Holl, Anna; Kapfhammer, Hans-Peter; Koppitz, Michael; Magnet, Markus; Otti, Daniela; Painold, Annamaria; Reisinger, Karin; Scheibl, Monika; Hecht, Karen; Lilek, Sabine; Müller, Nicole; Schöggl, Helmut; Ullah, Jasmin; Brugger, Florian; Hepperger, Caroline; Hotter, Anna; Seppi, Klaus; Wenning, Gregor; Buratti, Lisa; Hametner, Eva-Maria; Holas, Christiane; Hametner, Eva-Maria; Hussl, Anna; Poewe, Werner; Braunwarth, Eva-Maria; Sprenger, Fabienne; Müller, Christoph; Lilek, Stefan; Sinadinosa, Daniela; Walleczek, Anna Maria; Bonelli, Raphael M; Ladurner, Gunther; Staffen, Wolfgang; Flamez, Anja; Morez, V; de Raedt, Sylvie; Boogaerts, Andrea; Vandenberghe, Wim; van Reijen, Dimphna; Klempí?, Ji?í; Majerová, Veronika; Roth, Jan; Hartikainen, Päivi; Hiivola, Heli; Martikainen, Kirsti; Tuuha, Katri; Ignatius, Jaakko; Kärppä, Mikko; Åman, Jaana; Mustonen, Aki; Kajula, Outi; Santala, Maire; Allain, Philippe; Guérid, Marie-Anne; Gohier, Bénédicte; Olivier, Audrey; Prundean, Adriana; Scherer- Gagou, Clarisse; Verny, Christophe; Bost, Marie; Babiloni, Blandine; Debruxelles, Sabrina; Duché, Charlotte; Goizet, Cyril; Lafoucrière, Danielle; Jameau, Laetitia; Spampinato, Umberto; De Bruycker, Christelle; Cabaret, Maryline; Carette, Anne-Sophie; Defebvre, Luc; Decorte, Eric; Delval, Arnaud; Delliaux, Marie; Destee, Alain; Dujardin, Kathy; Peter, Mireille; Plomhouse, Lucie; Sablonnière, Bernard; Simonin, Clémence; Defebvre, Luc; Lemaire, Marie-Hélène; Manouvrier, Sylvie; Thibault-Tanchou, Stéphanie; Vuillaume, Isabelle; Krystkowiak, Pierre; Duru, Cécile; Roussel, Martine; Wannepain, Sandrine; Berrissoul, Hassan; Bellonet, Marcellin; Courtin, Françoise; Mantaux, Béatrice; Fasquel, Véronique; Godefroy, Olivier; Azulay, Jean-Philippe; Fluchère, Frédér- ique; Delfini, Marie; Eusebio, Alexandre; Mundler, Laura; Longato, Nadine; Rudolf, Gabrielle; Steinmetz, Gisèle; Tranchant, Christine; Wagner, Caroline; Zimmermann, Marie- Agathe; Marcel, Christophe; Calvas, Fabienne; Pariente, Jérémie; Démonet, Jean-François; Cheriet, Samia; Kosinski, Christoph Michael; Milkereit, Eva; Probst, Daniela; Reetz, Kathrin; Sass, Christian; Schiefer, Johannes; Schlangen, Christiane; Werner, Cornelius J; Gelderblom, Harald; Priller, Josef; Prüß, Harald; Spruth, Eike Jakob; Andrich, Jürgen; Ellrichmann, Gisa; Hoffmann, Rainer; Kaminski, Barbara; Saft, Carsten; Stamm, Christiane; Lange, Herwig; Bosredon, Cecile; Maass, Antonia; Schmidt, Simone; Storch, Alexander; Wolz, Martin; Kohl, Zacharias; Winkler, Jürgen; Capetian, Philipp; Lambeck, Johann; Zucker, Birgit; Boelmans, Kai; Ganos, Christos; Goerendt, Ines; Hidding, Ute; Lewerenz, Jan; Münchau, Alexander; Orth, Michael; Schmalfeld, Jenny; Stubbe, Lars; Zittel, Simone; Diercks, Gabriele; Dressler, Dirk; Gorzolla, Heike; Schrader, Christoph; Tacik, Pawel; Heinicke, Walburgis; Longinus, Bernhard; Bürk, Kathrin; Möller, Jens Carsten; Rissling, Ida; Mühlau, Mark; Peinemann, Alexander; Städtler, Michael; Weindl, Adolf; Winkelmann, Juliane; Ziegler, Cornelia; Bohlen, Stefan; Hölzner, Eva; Lange, Herwig; Reilmann, Ralf; Sass, Christian; Dose, Matthias; Leythaeuser, Gabriele; Marquard, Ralf; Raab, Tina; Schrenk, Caroline; Schuierer, Michele; Barth, Katrin; Buck, Andrea; Connemann, Julia; Ecker, Daniel; Eschenbach, Carolin; Held, Christine; Landwehrmeyer, Bernhard; Lezius, Franziska; Nepper, Solveig; Niess, Anke; Orth, Michael; Schwenk, Daniela; Süßmuth, Sigurd; Trautmann, Sonja; Weydt, Patrick; Cormio, Claudia; Sciruicchio, Vittorio; Serpino, Claudia; Tommaso, Marinade; Capellari, Sabina; Cortelli, Pietro; Gallassi, Roberto; Poda, Roberto; Rizzo, Giovanni; Scaglione, Cesa; Bertini, Elisabetta; Ghelli, Elena; Ginestroni, Andrea; Massaro, Francesca; Mechi, Claudia; Paganini, Marco; Piacentini, Silvia; Pradella, Silvia; Romoli, Anna Maria; Sorbi, Sandro; Abbruzzese, Giovanni; di Poggio, Monica Bandettini; Di Maria, Emilio; Ferrandes, Giovanna; Mandich, Paola; Marchese, Roberta; Albanese, Alberto; Di Bella, Daniela; Di Donato, Stefano; Gellera, Cinzia; Genitrini, Silvia; Mariotti, Caterina; Monza, Daniela; Nanetti, Lorenzo; Paridi, Dominga; Soliveri, Paola; Tomasello, Chiara; De Michele, Giuseppe; Di Maio, Luigi; Salvatore, Elena; Rinaldi, Carlo; Rossi, Fabiana; Massarelli, Marco; Roca, Alessandro; Ammendola, Sarah; Russo, Cinzia Valeria; Squitieri, Ferdinando; Elifani, Francesca; Maglione, Vittorio; Di Pardo, Alba; Alberti, Silvia; Griguoli, Annamaria; Amico, Enrico; Martino, Tiziana; Petrollini, Martina; Bentivoglio, Anna Rita; Catalli, Claudio; Di Giacopo, Raffaella; Fasano, Alfonso; Frontali, Marina; Guidubaldi, Arianna; Ialongo, Tamara; Jacopini, Gioia; Loria, Giovanna; Piano, Carla; Chiara, Piccininni; Quaranta, Davide; Romano, Silvia; Soleti, Francesco; Spadaro, Maria; Zinzi, Paola; Rinaldi, Carlo; Rossi, Fabiana; Massarelli, Marco; Roca, Alessandro; Ammendola, Sarah; Russo, Cinzia Valeria; Squitieri, Ferdinando; Elifani, Francesca; Maglione, Vittorio; Alberti, Silvia; Griguoli, Annamaria; Amico, Enrico; Martino, Tiziana; Petrollini, Martina; Bentivoglio, Anna Rita; Catalli, Claudio; Di Giacopo, Raffaella; Fasano, Alfonso; Frontali, Marina; Guidubaldi, Arianna; Ialongo, Tamara; Jacopini, Gioia; Loria, Giovanna; Piano, Carla; Chiara, Piccininni; Quaranta, Davide; Romano, Silvia; Soleti, Francesco; Spadaro, Maria; Zinzi, Paola; van Hout, Monique S E; van Vugt, Jeroen P P; Weert, A Maritde; Bolwijn, J J W; Dekker, M; Leenders, K L; Kremer, H P H; Bos, Reineke; Dumas, Eve M; van den Bogaard, Simon J A; Roos, Raymund A C; 't Hart, Ellen P; van Duijn, Erik; Økland, Ellen; Hauge, Erik; Tyvoll, Hilde; Heiberg, Arvid; Walsem, Marleen Rvan; Frich, Jan; Aaserud, Olaf; Wehus, Raghild; Bjørgo, Kathrine; Fannemel, Madeleine; Gørvell, Per; Lorentzen, Eirin; Koivisto, Susana Pro; Retterstøl, Lars; Overland, Torborg; Stokke, Bodil; Sando, Botne; Dziadkiewicz, Artur; Nowak, Malgorzata; Robowski, Piotr; Sitek, Emilia; Slawek, Jaroslaw; Soltan, Witold; Szinwelski, Michal; Blaszcyk, Magdalena; Boczarska-Jedynak, Magdalena; Ciach-Wysocka, Ewelina; Gorzkowska, Agnieszka; Jasinska-Myga, Barbara; Opala, Gregorz; K?odowska-Duda, Gabriela; Stompel, Daniel; Banaszkiewicz, Krzysztof; Bo?wi?ska, Dorota; Szczudlik, Andrzej; Rudzi?ska, Monika; Wójcik, Magdalena; Dec, Ma?gorzata; Krawczyk, Malgorzata; Jaremek, Kamila Bojakowska; Szczygie?, El?bieta; Stenwak, Agata; ielewska, Anna Was; Bryl, Anna; Ciesielska, Anna; Klimberg, Aneta; Marcinkowski, Jerzy; Sempo?owicz, Justyna; Zielonka, Daniel; Samara, Husam; Wi?niewski, Bart?omiej; Janik, Piotr; Gogol, Anna; Kwiecinski, Hubert; Jamrozik, Zygmunt; Kaminska, Anna; Antczak, Jakub; Jachinska, Katarzyna; Rakowicz, Maryla; Richter, Przemyslaw; Rola, Rafal; Ryglewicz, Danuta; Sienkiewicz-Jarosz, Halina; St?pniak, Iwona; Witkowski, Grzegorz; Zdzienicka, Elzbieta; Zaremba, Jacek; Su?ek, Anna; Krysa, Wioletta; St?pniak, Iwona; Zieora-Jakutowicz, Karolina; Júlio, Filipa; Januário, Cristina; Mestre, Tiago; Correia-Guedes, Leonor; Coelho, Miguel; Mendes, Tiago; Valadas, Anabela; Ferreira, Joaquim J; Timóteo, Ângela; Costa, Cristina; Cavaco, Sara; Damásio, Joana; Loureiro, Rui; Magalhães, Marina; Andrade, Carlos; Gago, Miguel; Garrett, Carolina; Guerra, Maria Rosália; Lima, Joana; Massano, João; Meireles, Joana; Herrera, Carmen Durán; Garcia, Patrocinio Moreno; Barrero, Francisco; Morales, Blas; Cubo, Esther; Mariscal, Natividad; Sánchez, Jesús; Alonso-Frech, Fernando; Perez, Maria Rabasa; Fenollar, María; García, Rocío García-Ramos; Quiroga, Purificacion Pin; Rivera, Susana Vázquez; Villanueva, Clara; Alegre, Javier; Bascuñana, Mónica; Caldentey, Juan Garcia; Ventura, Marta Fatás; Ribas, Guillermo García; Yébenes, Justo Garcíade; López-Sendón Moreno, José Luis; Cubillo, Patricia Trigo; García Ruíz, Pedro J; Martínez-Descals, Asunción; Artiga, María José Saiz; Sánchez, Vicenta; Guerrero, Rosa; Bárcenas, Antonio Herranz; Noguera Perea, María Fuensanta; Fortuna, Lorenza; Martirio, María; Torres, Antequera; Reinante, Gema; Moreau, Laura Vivancos; Barbera, Miquel Aguilar; Guia, Dolors Badenes; Hernanz, Laura Casas; Catena, Judit López; Sebastián, Ana Rojo; Ferrer, Pilar Quiléz; Carruesco, Gemma Tome; Bas, Jordi; Busquets, Núria; Calopa, Matilde; Elorza, Marina Dalmau; Díez-AjaLópez, Cristóbal; Terol, Santiago Durán-Sindreu; Robert, Misericordia Floriach; Ruíz, Belén Garzón; Casado, Ana González; Martínez, Isabel Haro; Viladrich, Celia Mareca; Càrdenas, Regina Ponsi; Roca, Elvira; Llesoy, Joan Roig; Idiago, Jesús Miguel Ruiz; Vergara, Mar Ruíz; García, Socorro Soriano; Riballo, Antonio Villa; González, Sonia González; Guisasola, Luis Menéndez; Salvador, Carlos; San Martín, Esther Suaréz; González, Mónica; Gorospe, Aranzazú; Legarda, Inés; Arques, Penelope Navas; Torres Rodríguez, María José; Vives, Barbara; Gaston, Itziar; Ramos-Arroyo, Maria A; Martinez-Jaurrieta, Maria Dolores; Manuel, Jose; Moreno, Garcia; Peña, José Chacón; Avarvarei, Luminita Dinca; Bastida, Antonio Martín; Recio, Maria Fernández; Vergé, Luis Redondo; Sánchez, Violeta Sánchez; Carrillo, Fátima; Cáceres, María Teresa; Mir, Pablo; Suarez, María José Lama; Bosca, Maria; Burguera, Juan Andres; Garcia, Anabel Campos; Brugada, Francisco Casterá; Martínez, Laura Martinez; Val, Javier Lópezdel; Loutfi, Ghada; Olofsson, Carina; Stattin, Eva-Lena; Westman, Laila; Wikström, Birgitta; lhagen, Sven E P; Paucar, Martin; Svenningsson, Per; Reza- Soltani, Tina Walldén; Höglund, Arja; Sandström, Britta; Wahlström, Jan; Høsterey-Ugander, Ulrika; Fredlund, Gunnel; Constantinescu, Radu; Neleborn-Lingefjärd, Liselotte; Tedr- off, Joakim; Esmaeilzadeh, Mona; Winnberg, Elisabeth; Pålhagen, Sven; Svennigsson, Per; Paucar, Martin; Riza-Soltani, Tina Waldèn; Sundblom, Jimmy; Johansson, Anders; Wiklund, Leif; Ekwall, Camilla; Göller, Marie-Louise; Petersén, Asa; Reimer, Jan; Widner, Hkan; Burgunder, Jean-Marc; Stebler, Yanik; Kaelin, Alain; Romero, Irene; Schüpbach, Michael; Weber, Sabine; Miedzybrodzka, Zosia; Rae, Daniela; Downie, Lorna; Simpson, Sheila; Summers, Fiona; Ure, Alexandra; Jack, Roisin; Matheson, Kirsty; Akhtar, Shahbana; Crooks, Jenny; Curtis, Adrienne; Souza, Jennyde; Rickards, Hugh; Wright, Jan; Hayward, Beverley; Sieradzan, Kasia; Wright, Abigail; Barker, Roger A; O'Keefe, Deidre; Di Pietro, Anna; Fisher, Kate; Hill, Susan; Mason, Sarah; Swain, Rachel; Valle, Natalie; Guzman; Bisson, Jonathan; Busse, Monica; Butcher, Cynthia; Callaghan, Jenny; Clenaghan, Catherine; Dunnett, Stephen; Fullam, Ruth; Handley, Olivia; Hunt, Sarah; Hughes, Alis; Johnstone, Catherine; Jones, Lesley; Jones, Una; Khalil, Hanan; Minster, Sara; Owen, Michael; Price, Kathleen; Rose, Linda Ellison; Townhill, Jenny; Rosser, Anne; Porteous, Mary; Edwards, Maureen; Ho, Carrie; McGill, Marie; Pearson, Pauline; Brockie, Peter; Foster, Jillian; Johns, Nicola; McKenzie, Sue; Rothery, Jean; Thomas, Gareth; Yates, Shona; Miller, Joanne; Ritchie, Stuart; Burrows, Liz; Fletcher, Amy; Harding, Alison; Laver, Fiona; Silva, Mark; Thomson, Aileen; Rowett, Liz; Gallantrae, Deena; Longthorpe, Mandy; Markova, Ivana; Raman, Ashok; Hamer, Stephanie; Wild, Sue; Yarduiman, Pam; Chu, Carol; Kraus, Alison; Wild, Sue; Yardumian, Pam; Musgrave, Hannah; Rowett, Liz; Toscano, Jean; Jamieson, Stuart; Hobson, Emma; Clayton, Carole; Dipple, Heather; Middleton, Julia; Freire-Patino, Dawn; Andrews, Thomasin; Dougherty, Andrew; Kavalier, Fred; Golding, Charlotte; Laing, Hana; Lashwood, Alison; Robertson, Dene; Ruddy, Deborah; Whaite, Anna; Santhouse, Alastair; Patton, Michael; Peterson, Maria; Rose, Sarah; Andrews, Thomasin; Bruno, Stefania; Chu, Elvina; Doherty, Karen; Golding, Charlotte; Haider, Salman; Hensman, Davina; Lahiri, Nayana; Lewis, Monica; Novak, Marianne; Patel, Aakta; Robertson, Nicola; Rosser, Elisabeth; Tabrizi, Sarah; Taylor, Rachel; Warner, Thomas; Wild, Edward; Craufurd, David; Fullam, Ruth; Howard, Liz; Sollom, Andrea; Snowden, Julie; Thompson, Jennifer; Callaghan, Jenny; Jones, Mary; Murphy, Helen; Trender-Gerhard, Iris; Rogers, Dawn; Bek, Judith; Oughton, Emma; Johnson, Liz; Hare, Marianne; Arran, Natalie; Verstraelen, Nichola; Partington-Jones, Lucy; Huson, Susan; Stopford, Cheryl; Westmoreland, Leann; Davidson, Jill; Morgan, Karen; Savage, Lois; Singh, Baldev; Komati, Suresh; Nemeth, Andrea H; Armstrong, Richard; Valentine, Ruth; Siuda, Gill; Harrison, David; Hughes, Max; Parkinson, Andrew; Soltysiak, Beverley; Burn, John; Coleman, Caroline; Bandmann, Oliver; Bradbury, Alyson; Gill, Paul; Fairtlough, Helen; Fillingham, Kay; Foustanos, Isabella; Kazoka, Mbombe; O'Donovan, Kirsty; Peppa, Nadia; Taylor, Catherine; Tidswell, Katherine; Quarrell, Oliver     «

Hubers, Anna A M; van Duijn, Erik; Roos, Raymund A C; Craufurd, David; Rickards, Hugh; Bernhard Landwehrmeyer, G; van der Mast, Rose C; Giltay, Erik J; REGISTRY investigators of the European Huntington's Disease Network; Bachoud-Lévi, A-C; Bentivoglio, A R; Biunno, I; Bonelli, R M; Burgunder, J-M; Dunnett, S B; Ferreira, J J; Handley, O J; Heiberg, A; llmann, T I; Landwehrmeyer, G B; Levey, J; Ramos-Arroyo, Maria A; Nielsen, J E; ProKoivisto, S; Päivärinta, M; Roos, R A C; Rojo Sebastián, A; Tab...     »

Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.     «

Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measureme...     »