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Title:

Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Stroh, Albrecht; Adelsberger, Helmuth; Groh, Alexander; Rühlmann, Charlotta; Fischer, Sebastian; Schierloh, Anja; Deisseroth, Karl; Konnerth, Arthur
Abstract:
Corticothalamic slow oscillations of neuronal activity determine internal brain states. At least in the cortex, the electrical activity is associated with large neuronal Ca(2+) transients. Here we implemented an optogenetic approach to explore causal features of the generation of slow oscillation-associated Ca(2+) waves in the in vivo mouse brain. We demonstrate that brief optogenetic stimulation (3-20 ms) of a local group of layer 5 cortical neurons is sufficient for the induction of global bra...     »
Journal title abbreviation:
Neuron
Year:
2013
Journal volume:
77
Journal issue:
6
Pages contribution:
1136-50
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuron.2013.01.031
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23522048
Print-ISSN:
0896-6273
TUM Institution:
Institut für Neurowissenschaften
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