Benutzer: Gast  Login
Titel:

Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Stroh, Albrecht; Adelsberger, Helmuth; Groh, Alexander; Rühlmann, Charlotta; Fischer, Sebastian; Schierloh, Anja; Deisseroth, Karl; Konnerth, Arthur
Abstract:
Corticothalamic slow oscillations of neuronal activity determine internal brain states. At least in the cortex, the electrical activity is associated with large neuronal Ca(2+) transients. Here we implemented an optogenetic approach to explore causal features of the generation of slow oscillation-associated Ca(2+) waves in the in vivo mouse brain. We demonstrate that brief optogenetic stimulation (3-20 ms) of a local group of layer 5 cortical neurons is sufficient for the induction of global bra...     »
Zeitschriftentitel:
Neuron
Jahr:
2013
Band / Volume:
77
Heft / Issue:
6
Seitenangaben Beitrag:
1136-50
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.neuron.2013.01.031
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23522048
Print-ISSN:
0896-6273
TUM Einrichtung:
Institut für Neurowissenschaften
 BibTeX