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Titel:

NONO couples the circadian clock to the cell cycle.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kowalska, E; Ripperger, JA; Hoegger, DC; Bruegger, P; Buch, T; Birchler, T; Mueller, A; Albrecht, U; Contaldo, C; Brown, SA
Abstract:
Mammalian circadian clocks restrict cell proliferation to defined time windows, but the mechanism and consequences of this interrelationship are not fully understood. Previously we identified the multifunctional nuclear protein NONO as a partner of circadian PERIOD (PER) proteins. Here we show that it also conveys circadian gating to the cell cycle, a connection surprisingly important for wound healing in mice. Specifically, although fibroblasts from NONO-deficient mice showed approximately norm...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2013
Band / Volume:
110
Heft / Issue:
5
Seitenangaben Beitrag:
1592-9
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1213317110
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23267082
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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