Metabolic safety of growth hormone in type 1 diabetes and idiopathic growth hormone deficiency.

Bonfig, Walter; Molz, Katharina; Woelfle, Joachim; Hofer, Sabine E; Hauffa, Berthold P; Schoenau, Eckhard; Golembowski, Sven; Wudy, Stefan A; Holl, Reinhard W

doi:10.1016/j.jpeds.2013.04.045

journal article

Titel:: Metabolic safety of growth hormone in type 1 diabetes and idiopathic growth hormone deficiency.
Dokumenttyp:: Journal Article
Autor(en):: Bonfig, Walter; Molz, Katharina; Woelfle, Joachim; Hofer, Sabine E; Hauffa, Berthold P; Schoenau, Eckhard; Golembowski, Sven; Wudy, Stefan A; Holl, Reinhard W
Abstract:: To evaluate metabolic consequences of growth hormone (GH) treatment in children with type 1 diabetes.This study is an analysis of metabolic changes in 37 patients with childhood-onset GH deficiency and type 1 diabetes, documented in the Diabetes Patienten Verlaufsdocumentationsystem database. Main outcome measures were changes in hemoglobin A1c and daily insulin requirements during GH therapy in children with GH deficiency and type 1 diabetes compared with a large cohort of adolescents with type 1 diabetes.Thirty-seven patients with type 1 diabetes and a diagnosis of idiopathic GH deficiency after onset of diabetes were compared with 48856 patients with type 1 diabetes. After adjustment for age, sex, duration of diabetes, and migration background, a significant difference in mean daily insulin requirement was seen between the 2 groups (1.0 IU/kg/day in subjects with GH deficiency and type 1 diabetes vs 0.85 IU/kg/day in controls; P < .01) and height-SDS (-2.0 in subjects with GH deficiency and diabetes vs +0.03 in controls; P < .0001). There was no significant between-group difference in hemoglobin A1 concentration, however (8.1% ± 1.4% in patients with GH deficiency and type 1 diabetes vs 8.2% ± 1.7% in those with type 1 diabetes only; P > .05).An increased daily insulin requirement should be considered in patients with type 1 diabetes treated with GH. With adequate adaptation of insulin dosage, metabolic control is not impaired during GH treatment.
Zeitschriftentitel:: J Pediatr
Jahr:: 2013
Band / Volume:: 163
Heft / Issue:: 4
Seitenangaben Beitrag:: 1095-8.e4
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.jpeds.2013.04.045
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/23746867
Print-ISSN:: 0022-3476
TUM Einrichtung:: Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Kinder- und Jugendmedizin (Prof. Hauer)2013