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Titel:

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schwitalla, Sarah; Ziegler, Paul K; Horst, David; Becker, Valentin; Kerle, Irina; Begus-Nahrmann, Yvonne; Lechel, André; Rudolph, K Lenhard; Langer, Rupert; Slotta-Huspenina, Julia; Bader, Franz G; Prazeres da Costa, Olivia; Neurath, Markus F; Meining, Alexander; Kirchner, Thomas; Greten, Florian R
Abstract:
Loss of p53 is considered to allow progression of colorectal tumors from the adenoma to the carcinoma stage. Using mice with an intestinal epithelial cell (IEC)-specific p53 deletion, we demonstrate that loss of p53 alone is insufficient to initiate intestinal tumorigenesis but markedly enhances carcinogen-induced tumor incidence and leads to invasive cancer and lymph node metastasis. Whereas p53 controls DNA damage and IEC survival during the initiation stage, loss of p53 during tumor progressi...     »
Zeitschriftentitel:
Cancer Cell
Jahr:
2013
Band / Volume:
23
Heft / Issue:
1
Seitenangaben Beitrag:
93-106
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ccr.2012.11.014
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23273920
Print-ISSN:
1535-6108
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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