Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

The glycophorin A transmembrane sequence within integrin ?v?3 creates a non-signaling integrin with low basal affinity that is strongly adhesive under force.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Müller, Martina A; Opfer, Jan; Brunie, Leonora; Volkhardt, Lilli A; Sinner, Eva-Kathrin; Boettiger, David; Bochen, Alexander; Kessler, Horst; Gottschalk, Kay-Eberhard; Reuning, Ute
Abstract:
Integrin heterodimeric cell adhesion and signaling receptors bind ligands of the extracellular matrix and relay signals bidirectionally across cell membranes. Thereby, integrins adopt multiple conformational and functional states that control ligand binding affinity and linkage to cytosolic/cytoskeletal proteins. Here, we designed an integrin chimera encompassing the strongly dimerizing transmembrane domain (TMD) of glycophorin A (GpA) in the context of the otherwise unaltered integrin ?v?3. We...     »
Zeitschriftentitel:
J Mol Biol
Jahr:
2013
Band / Volume:
425
Heft / Issue:
16
Seitenangaben Beitrag:
2988-3006
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jmb.2013.05.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23727145
Print-ISSN:
0022-2836
TUM Einrichtung:
Frauenklinik und Poliklinik
 BibTeX