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Title:

NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium.

Document type:
Journal Article; Article
Author(s):
Felmy, B; Songhet, P; Slack, EM; Müller, AJ; Kremer, M; Van Maele, L; Cayet, D; Heikenwalder, M; Sirard, JC; Hardt, WD
Abstract:
Infections, microbe sampling and occasional leakage of commensal microbiota and their products across the intestinal epithelial cell layer represent a permanent challenge to the intestinal immune system. The production of reactive oxygen species by NADPH oxidase is thought to be a key element of defense. Patients suffering from chronic granulomatous disease are deficient in one of the subunits of NADPH oxidase. They display a high incidence of Crohn's disease-like intestinal inflammation and are...     »
Journal title abbreviation:
PLoS ONE
Year:
2013
Journal volume:
8
Journal issue:
10
Pages contribution:
e77204
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0077204
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24143212
Print-ISSN:
1932-6203
TUM Institution:
Institut für Virologie
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