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Title:

Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Nagel, J; Gross, B; Meggendorfer, M; Preiss, C; Grez, M; Brack-Werner, R; Dietzel, S
Abstract:
The large-scale chromatin organization of retrovirus and retroviral gene vector integration loci has attracted little attention so far. We compared the nuclear organization of transcribed integration loci with the corresponding loci on the homologous chromosomes. Loci containing gamma-retroviral gene transfer vectors in mouse hematopoietic precursor cells showed small but significant repositioning of the integration loci towards the nuclear interior. HIV integration loci in human cells showed a...     »
Journal title abbreviation:
Chromosoma
Year:
2012
Journal volume:
121
Journal issue:
4
Pages contribution:
353-67
Language:
eng
Fulltext / DOI:
doi:10.1007/s00412-012-0366-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22415776
Print-ISSN:
0009-5915
TUM Institution:
Institut für Virologie
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