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Title:

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Grienberger, C; Rochefort, NL; Adelsberger, H; Henning, HA; Hill, DN; Reichwald, J; Staufenbiel, M; Konnerth, A
Abstract:
The accumulation of amyloid-? in the brain is an essential feature of Alzheimer's disease. However, the impact of amyloid-?-accumulation on neuronal dysfunction on the single cell level in vivo is poorly understood. Here we investigate the progression of amyloid-? load in relation to neuronal dysfunction in the visual system of the APP23×PS45 mouse model of Alzheimer's disease. Using in vivo two-photon calcium imaging in the visual cortex, we demonstrate that a progressive deterioration of neuro...     »
Journal title abbreviation:
Nat Commun
Year:
2012
Journal volume:
3
Pages contribution:
774
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms1783
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22491322
Print-ISSN:
2041-1723
TUM Institution:
Institut für Neurowissenschaften
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