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Titel:

The effects of GluA1 deletion on the hippocampal population code for position.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Article
Autor(en):
Resnik, E; McFarland, JM; Sprengel, R; Sakmann, B; Mehta, MR
Abstract:
The GluA1 subunit of AMPA receptors (AMPARs) is critical for hippocampal synaptic transmission and plasticity. Here, we measured the activity of single units from the CA1 region of the hippocampus while GluA1 knock-out (GluA1?/?) and wild-type (WT) mice traversed a linear track. Although overall firing rates were similar, GluA1?/? neurons were more likely to spike in bursts, but at lower burst frequencies, compared with WT neurons. GluA1?/? neurons showed large reductions in all measures of spat...     »
Zeitschriftentitel:
J Neurosci
Jahr:
2012
Band / Volume:
32
Heft / Issue:
26
Seitenangaben Beitrag:
8952-68
Sprache:
eng
Volltext / DOI:
doi:10.1523/JNEUROSCI.6460-11.2012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22745495
Print-ISSN:
0270-6474
TUM Einrichtung:
Institut für Neurowissenschaften
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