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Titel:

The endocytic adaptor Eps15 controls marginal zone B cell numbers.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Pozzi, B; Amodio, S; Lucano, C; Sciullo, A; Ronzoni, S; Castelletti, D; Adler, T; Treise, I; Betsholtz, IH; Rathkolb, B; Busch, DH; Wolf, E; Fuchs, H; Gailus-Durner, V; de Angelis, MH; Betsholtz, C; Casola, S; Di Fiore, PP; Offenhauser, N
Abstract:
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-KO mice to investigate its function in mammals. Eps15-KO mice are born at the expected Mendelian ratio and are fertile. Using a large-scale phenotype screen covering more than 300 parameters correlated to human disease, we found that Eps15-KO mi...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
11
Seitenangaben Beitrag:
e50818
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0050818
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23226392
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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