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Title:

Decreased cardiac L-type Ca²? channel activity induces hypertrophy and heart failure in mice.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Goonasekera, SA; Hammer, K; Auger-Messier, M; Bodi, I; Chen, X; Zhang, H; Reiken, S; Elrod, JW; Correll, RN; York, AJ; Sargent, MA; Hofmann, F; Moosmang, S; Marks, AR; Houser, SR; Bers, DM; Molkentin, JD
Abstract:
Antagonists of L-type Ca²? channels (LTCCs) have been used to treat human cardiovascular diseases for decades. However, these inhibitors can have untoward effects in patients with heart failure, and their overall therapeutic profile remains nebulous given differential effects in the vasculature when compared with those in cardiomyocytes. To investigate this issue, we examined mice heterozygous for the gene encoding the pore-forming subunit of LTCC (calcium channel, voltage-dependent, L type, ?1C...     »
Journal title abbreviation:
J Clin Invest
Year:
2012
Journal volume:
122
Journal issue:
1
Pages contribution:
280-90
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI58227
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22133878
Print-ISSN:
0021-9738
TUM Institution:
Institut für Pharmakologie und Toxikologie
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