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Title:

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Luo, C; Gangadharan, V; Bali, KK; Xie, RG; Agarwal, N; Kurejova, M; Tappe-Theodor, A; Tegeder, I; Feil, S; Lewin, G; Polgar, E; Todd, AJ; Schlossmann, J; Hofmann, F; Liu, DL; Hu, SJ; Feil, R; Kuner, T; Kuner, R
Abstract:
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states. Previous studies have functionally implicated the NMDA receptor-NO pathway and the downstream second messenger, cGMP, in these processes. Because cGMP can broadly influence diverse ion-channels, kinases, and phosphodiesterases, pre- as well as post-synaptically, the precise ide...     »
Journal title abbreviation:
PLoS Biol
Year:
2012
Journal volume:
10
Journal issue:
3
Pages contribution:
e1001283
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pbio.1001283
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22427743
Print-ISSN:
1544-9173
TUM Institution:
Institut für Pharmakologie und Toxikologie
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