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Titel:

Decreased cardiac L-type Ca²? channel activity induces hypertrophy and heart failure in mice.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Goonasekera, SA; Hammer, K; Auger-Messier, M; Bodi, I; Chen, X; Zhang, H; Reiken, S; Elrod, JW; Correll, RN; York, AJ; Sargent, MA; Hofmann, F; Moosmang, S; Marks, AR; Houser, SR; Bers, DM; Molkentin, JD
Abstract:
Antagonists of L-type Ca²? channels (LTCCs) have been used to treat human cardiovascular diseases for decades. However, these inhibitors can have untoward effects in patients with heart failure, and their overall therapeutic profile remains nebulous given differential effects in the vasculature when compared with those in cardiomyocytes. To investigate this issue, we examined mice heterozygous for the gene encoding the pore-forming subunit of LTCC (calcium channel, voltage-dependent, L type, ?1C...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2012
Band / Volume:
122
Heft / Issue:
1
Seitenangaben Beitrag:
280-90
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI58227
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22133878
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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