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Titel:

Synthetic protein-conductive membrane nanopores built with DNA

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Diederichs, T.; Pugh, G.; Dorey, A.; Xing, Y.; Burns, J.R.; Nguyen, Q.H.; Tornow, M.; Tampé, R.; Howorka, S.
Abstract:
Nanopores are key in portable sequencing and research given their ability to transport elongated DNA or small bioactive molecules through narrow transmembrane channels. Transport of folded proteins could lead to similar scientific and technological benefits. Yet this has not been realised due to the shortage of wide and structurally defined natural pores. Here we report that a synthetic nanopore designed via DNA nanotechnology can accommodate folded proteins. Transport of fluorescent proteins th...     »
Zeitschriftentitel:
Nat Commun 10, 5018 2019-11
Jahr:
2019
Jahr / Monat:
2019-11
Quartal:
4. Quartal
Monat:
Nov
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1038/s41467-019-12639-y
WWW:
https://www.nature.com/articles/s41467-019-12639-y
Verlag / Institution:
nature physics
TUM Einrichtung:
Professur für Molekularelektronik
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