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Title:

HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Ghiglione, Y; Rodríguez, AM; De Candia, C; Carobene, M; Benaroch, P; Schindler, M; Salomón, H; Turk, G
Abstract:
HIV Nef-mediated up-regulation of invariant chain (Ii chain, also CD74) is presumed to play an active role in HIV immunopathogenesis. However, this has not been definitely ascertained. In order to help elucidate this hypothesis, Ii chain, CD4, HLA-DR and HLA-ABC expression was analyzed ex vivo in monocyte-derived macrophages (MDMs) from HIV(+) subjects. Viral load, CD4(+) T cell count and immune activation were also determined in enrolled subjects. Correlations between these parameters and the m...     »
Journal title abbreviation:
Virus Res
Year:
2012
Journal volume:
163
Journal issue:
1
Pages contribution:
380-4
Language:
eng
Fulltext / DOI:
doi:10.1016/j.virusres.2011.09.011
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21945129
Print-ISSN:
0168-1702
TUM Institution:
Institut für Virologie
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