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Titel:

Therapeutic implications for the induced levels of chk1 in myc-expressing cancer cells.

Dokumenttyp:
Journal Article
Autor(en):
Höglund, A; Nilsson, LM; Muralidharan, SV; Hasvold, LA; Merta, P; Rudelius, M; Nikolova, V; Keller, U; Nilsson, JA
Abstract:
The transcription factor c-Myc (or "Myc") is a master regulator of pathways driving cell growth and proliferation. MYC is deregulated in many human cancers, making its downstream target genes attractive candidates for drug development. We report the unexpected finding that B-cell lymphomas from mice and patients exhibit a striking correlation between high levels of Myc and checkpoint kinase 1 (Chk1).By in vitro cell biology studies as well as preclinical studies using a genetically engineered mo...     »
Zeitschriftentitel:
Clin Cancer Res
Jahr:
2011
Band / Volume:
17
Heft / Issue:
22
Seitenangaben Beitrag:
7067-79
Sprache:
eng
Volltext / DOI:
doi:10.1158/1078-0432.CCR-11-1198
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21933891
Print-ISSN:
1078-0432
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie
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