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Titel:

Early life environment determines the development of adult phobic-like fear responses in BALB/cAnN mice.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Thoeringer, CK; Pfeiffer, UJ; Rammes, G; Pamplona, FA; Moosmang, S; Wotjak, CT
Abstract:
Environmental factors may unleash genetically determined susceptibility to psychopathology. Great effort has been spent in identifying both the genetic basis and environmental sources of exaggerated fear in animal models of anxiety disorders. Here, we show that the origin of inbred mice, probably via subtle differences in breeding and rearing conditions, may have large consequences specifically on acquisition and retention of fear memories, while leaving anxiety-related behaviours unaffected. Th...     »
Zeitschriftentitel:
Genes Brain Behav
Jahr:
2010
Band / Volume:
9
Heft / Issue:
8
Seitenangaben Beitrag:
947-57
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1601-183X.2010.00634.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20659172
Print-ISSN:
1601-1848
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie; Klinik für Anästhesiologie (DHM)
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