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Titel:

Persistence of effector memory Th1 cells is regulated by Hopx.

Dokumenttyp:
Journal Article
Autor(en):
Albrecht, I; Niesner, U; Janke, M; Menning, A; Loddenkemper, C; Kuhl, AA; Lepenies, I; Lexberg, MH; Westendorf, K; Hradilkova, K; Grün, J; Hamann, A; Epstein, JA; Chang, HD; Tokoyoda, K; Radbruch, A
Abstract:
Th1 cells are prominent in inflamed tissue, survive conventional immunosuppression, and are believed to play a pivotal role in driving chronic inflammation. Here, we identify homeobox only protein (Hopx) as a critical and selective regulator of the survival of Th1 effector/memory cells, both in vitro and in vivo. Expression of Hopx is induced by T-bet and increases upon repeated antigenic restimulation of Th1 cells. Accordingly, the expression of Hopx is low in peripheral, naïve Th cells, but hi...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2010
Band / Volume:
40
Heft / Issue:
11
Seitenangaben Beitrag:
2993-3006
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.201040936
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21061432
Print-ISSN:
0014-2980
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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