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Titel:

In vivo imaging of macrophage activity in the coronary arteries using 68Ga-DOTATATE PET/CT: correlation with coronary calcium burden and risk factors.

Dokumenttyp:
Journal Article
Autor(en):
Rominger, Axel; Saam, Tobias; Vogl, Eva; Ubleis, Christopher; la Fougère, Christian; Forster, Stefan; Haug, Alexander; Cumming, Paul; Reiser, Maximilian F; Nikolaou, Konstantin; Bartenstein, Peter; Hacker, Marcus
Abstract:
We measured the uptake of the somatostatin receptor ligand (68)Ga-[1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid]-D-Phe(1),Tyr(3)-octreotate (DOTATATE) in the left anterior descending coronary artery (LAD) in association with calcified plaques (CPs) and cardiovascular risk factors.Seventy consecutive tumor patients were examined by whole-body (68)Ga-DOTATATE contrast-enhanced PET/CT. Blood-pool-corrected standardized uptake value (target-to-background ratio) was measured in the LAD, and CT images were used to detect CP. Cardiovascular risk factors and history of prior cardiovascular events were recorded.(68)Ga-DOTATATE uptake was detectable in the LAD of all patients. Target-to-background ratio in the LAD correlated significantly with the presence of CP (R = 0.34; P < 0.01), prior vascular events (R = 0.26; P < 0.05), and male sex (R = 0.29; P < 0.05), whereas CP correlated with these parameters but also with age (R = 0.34; P < 0.01) and hypertension (R = 0.25; P < 0.05).In a series of oncologic patients, those with prior cardiovascular events and calcified atherosclerotic plaques showed significantly increased (68)Ga-DOTATATE uptake in the LAD, suggesting a potential role of this tracer for plaque imaging in the coronary arteries.
Zeitschriftentitel:
J Nucl Med
Jahr:
2010
Band / Volume:
51
Heft / Issue:
2
Seitenangaben Beitrag:
193-7
Sprache:
eng
Volltext / DOI:
doi:10.2967/jnumed.109.070672
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20080898
Print-ISSN:
0161-5505
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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