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Titel:

Interleukin 6/interleukin 6 receptor interaction and its role as a therapeutic target for treatment of cachexia and cancer.

Dokumenttyp:
Journal Article; Review
Autor(en):
Weidle, UH; Klostermann, S; Eggle, D; Kruger, A
Abstract:
Interleukin 6 (IL6) mediates pleiotropic physiological functions through its interaction with the IL6 receptor (IL6R). Signal transduction can occur via cis- and trans-signaling. The role of IL6/IL6R interaction via autocrine and paracrine loops in tumor proliferation and progression is discussed. The potential role of IL6/IL6R interaction in different experimental systems and tumor entities is summarized while the focus is on inhibition of IL6 signaling with monoclonal antibodies directed again...     »
Zeitschriftentitel:
Cancer Genomics Proteomics
Jahr:
2010
Band / Volume:
7
Heft / Issue:
6
Seitenangaben Beitrag:
287-302
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21156962
Print-ISSN:
1109-6535
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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