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Title:

The xenoestrogen bisphenol A in the Hershberger assay: Androgen receptor regulation and morphometrical reactions indicate no major effects

Document type:
Zeitschriftenaufsatz
Author(s):
Nishino T, Wedel T, Schmitt O, Schoenfelder M, Hirtreiter C, Schulz T, Kuhnel W, Michna H
Abstract:
We evaluated androgen-like effects of bisphenol A (BPA) using orchiectomized Wistar rats. Animals were treated p.o. either with vehicle or with 3, 50, 200, 500 mg/kg bw/day BPA (n = 13) for 7 days. One group was treated s.c. with 1 mg/kg bw/day testosterone propionate (TP). Flutamide (FL) (3 mg/kg bw/day, p.o.) was used to antagonize androgen effects of the suprapharmacological dose (500 mg/kg bw/day) of BPA. Androgen-like effects of BPA on prostates and seminal vesicles were assessed by the Her...     »
Keywords:
Bisphenol A Prostate Seminal vesicle Immunohistochemistry Morphometry Densitometry Androgen receptor regulation PCNA MIB-5 Proliferation markers
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:
Journal of Steroid Biochemistry and Molecular Biology
Year:
2006
Journal volume:
98
Year / month:
2006-02
Journal issue:
(2-3)
Pages contribution:
155-163
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:https://doi.org/10.1016/j.jsbmb.2005.08.019
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16406770
Print-ISSN:
0960-0760
Semester:
WS 05-06
TUM Institution:
Sportbiologie
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